This has previously limited our ability to investigate the microstructure and connectivity of these pathways and, as a result, they are relatively poorly understood. corpus callosum, cingulate bundle, and longitudinal fasciculi), the connections of the hippocampal formation to other brain regions are narrower and more tortuous 1, therefore offering a greater challenge to techniques such as MRI. Compared to other major WM pathways of the brain (e.g. Macroscopic extra-hippocampal connections are less well described likely due to technical limitations regarding how well these pathways can be evaluated. Most imaging studies of the hippocampus have focussed on either the morphology of the hippocampal formation or on intra-hippocampal microcircuitry. The hippocampus is implicated in a range of diseases and normal functions, however a detailed understanding of the structural connections of the hippocampus is currently lacking. The hippocampus is considered the key component of the Papez circuit, which is generally described as the “emotional circuit” encompassing the medial temporal lobe (MTL: hippocampus, amygdala, and entorhinal cortex), hypothalamus, septum, prefrontal cortex, and the white matter (WM) circuitry connecting them. The hippocampus is one of the oldest regions of the brain (the archicortex), and has wide-reaching connections. Our findings extend the collective knowledge of hippocampal anatomy, highlighting the importance of the spinal-limbic pathway and the striking lack of hippocampal connectivity with motor and sensory cortices. Overall, our results concur with preclinical and ex-vivo data, confirming that meaningful in vivo characterisation of hippocampal connections is possible in an individual. There was a strong age dependence of hippocampal connectivity to medial occipital regions. The strongest individual connection was to the ipsilateral thalamus. Using a connectomic approach, we identified six dominant pathways in terms of strength, length and anatomy, and characterised them by their age and gender variation. We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (n = 94 391-directions). He has published more than 50 articles in peer-reviewed journals as well as several book chapters.The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain. Risold is a member of the Société de Neuroendocrinologie and Société des Neurosciences.
As CR1 INSERM he returned to the Histology Laboratory (EA 3922) in Besançon in 1997. He subsequently performed postdoctoral studies at the University of Southern California, Los Angeles, in the course of which he analyzed the anatomical relationships of the hippocampus with the septum and hypothalamus.
Pierre-Yves Risold completed his PhD thesis at the Histology Laboratory, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon in 1991. Cattin is the author of a number of articles in peer-reviewed journals and has co-authored or co-edited several previous books, including Computed Tomography of the Pituitary Gland (Springer, 1986) and three editions of Echo-Doppler des artères carotides et vertébrales: aspects pratiques (Masson). Her memberships include the Société Française de Neuroradiologie, the Société Française de Radiologie, and the Société européenne de Neuroradiologie. In 1996-7 she completed a Visiting Professorship at Montreal Neurological Hospital, McGill University, Canada. Naidich and others).įrançoise Cattin completed her medical thesis in 1980 and since 1986 has worked at CHU Besançon, France.
#HIPPOCAMPUS ANATOMY SAGITTAL MRI SERIAL#
He has been the author of numerous publications over several decades, and has published a number of previous books with Springer, including The Superficial Veins of the Human Brain (1975), The Human Brain Stem and Cerebellum (1995), The Human Hippocampus Functional Anatomy: Vascularization and Serial Sections with MRI, 3 rd edn (2005) and Duvernoy’s Atlas of the Human Brain Stem and Cerebellum (2009 co-authored with T.P. Duvernoy has had a distinguished career in the field, working as a Professor of Anatomy until 1999, since which time he has been Emeritus Professor at the University of Franche-Comté, Besançon, France.
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